Speech Writing

Read the following discussion and consider the views of both the teacher and her students. Write a speech for the school Science Club. In your speech ; describe some of the ways children use technology ; precautions children could take for health and safety ; views of older generations towards technology ; give your own views Base your speech on the ideas found in the discussion and be careful to use your own words. You should write between lo and 2 sides, allowing for the size of your handwriting.Up to ten marks are available for the content of your answer and up to fifteen marks for the quality Of your writing. After a Communication Studies lesson, the teacher, Mrs. Trapdoor, and three students discuss modern technology. Mrs. Trapdoor: That lesson makes me more worried than ever about your physical well being. Surely it's not a good thing that you use modern technology to escape from reality so often? Brat: So, what do you do to escape from the stresses of your job? No doubt you â €˜up the volume' on your classical music in the car or watch the latest soap opera on television.Either way, it's not that different. Mrs. Trapdoor: Okay, we all need to switch off now and then, but the kids see are permanently hooked up to some gadget that Stops them communicating with others. My son is constantly in his own bubble; if he's not on the phone to a friend then he's ‘shuffling' and focused on his music player, and don't get me started on these new games and films he watches on a ridiculously small screen. Catkin: It's the latest technology. It solves the problem of what film you all want to watch on television.He's just ‘zoning out'; its what we all do. In your day you would have gone to your room. Well, now we can block out situations hat are stressful. Mrs. Trapdoor: What? Like family life? You see that's what worries me. He's there in the room with us, but he's not really there. Ail: Well, it depends on how high the volume is! I can easily listen to m y music as well as tune in to what's being said around me. If my mother starts an argument, then I just turn the volume up to the maximum! Brat: That's how I like to listen to my music nanny. Loud.Mrs. Trapdoor: You see that also concerns me. New studies prove it is dangerous to listen to really loud music as it can cause hearing loss. [25] Catkin: Well, what about you and your laptop? You're always hunched over it typing, risking injury to your back and your hands. You see, you condemn our use of technology, but you forget how much people older than us rely on it. Plus, if anything goes wrong with your new devices, you usually ask us to fix it. Mrs. Trapdoor: Okay, I know you belong to the technological society, but it doesn't stop me worrying about your health.My laptop isn't a miniscule gadget that requires me to risk my eyesight to see the screen. The keys on your game players are so small that you could suffer from repetitive strain injury or even arthritis in the future. Catki n: get your point. However, we know that we should have breaks when our eyes get tired or our fingers ache. Mrs. Trapdoor: What about the dangers of walking around or cycling whilst the latest rap song is blaring in your ears? You're oblivious to the traffic around you and you risk being in an accident.What's more, someone could attack you as you wouldn't be aware of their presence. Ail: It is stupid to lock yourself up in your own world in a busy city, but is it very different from adult motorists talking on their mobiles and causing accidents? Mrs. Trapdoor: But it's in cities where I see most teenagers not interacting with hats going on around them, and they don't even mutter please or thank you to others who serve them. Ail: You can't blame these devices for bad manners. Don't tell me that adults aren't tempted to block out the noise and stress of public transport!I saw an old guy with headphones on in the subway, blissfully unaware of his surroundings. Mrs. Trapdoor: Everyone o ver thirty looks old to you lot! My point is still relevant. I'm not just concerned about noise. I've even heard of discos where teenagers listen and dance to their own choice of music on their own headphones. Catkin: Hey, that's a good idea! The world is changing. By the way, is that your cell phone ringing? A very warm welcome to one and all in the Science Club ! Does any one here know that technology could be dated back to the pre historic era?Well, before we get into that, lets define technology. As we all know , our lives revolve around technological advancements right from basic appliances like a fan or air conditioner to your Phone. Engineers all over the world strive to improve the quality of life, by inventing user friendly devices by which, life becomes comfortable. Who could say ‘NO' to ease and luxury in the fast advancing world Nicola Tests, the father of modern technology, as ridiculed by scientists then for inventing very important tools like the radio, Cray & the AC and DC motor.Some did not accept his theory, but least did they imagine, so many years later a life without these modern appliances. Technology should be encouraged when it comes to enriching a person's being. The very discovery of the ‘flint' stone is considered a technological advancement without which the discovery of fire would have been next to impossible. As the saying goes ‘Necessity is the mother of invention', the thirst and desire to learn and aspire is what drove cave man to improve his lifestyle. If only he did not do so, we would all remain in darkness till date.Since then, discoveries big or small have had a positive impact on the outlook of people and the way they choose to lead life. Not only has technology impacted the world towards fun and enjoyment, but also helped him have a larger life span , thanks to the advancements in the field Of healthcare. Technology alone has helped diagnose and treat life threatening diseases that could possibly wipe out our very existence on this planet. Hence, encouraging such endeavourers is an important step towards a healthy life. The past decade has seen profound increase in the use of entertainment technology by children, some as young as 1 year of age.It is hard to find kids who would prefer playing basket ball in the open to a SSP indoors. Doctors world wide believe , that ‘attachment' to technology has ‘detached' children from humanity as they would interact better with a Graphical User Interface than a fellow human being. Brain development research suggests that the frontal cortex of a child's brain is at risk where he looses impulse control and becomes more violent. Apart from this, the Electromagnetic radiations that are emitted from these gadgets are remarry causes of sensory and motor disorders in children.Being a couch potato , with a TV remote in one hand and a snack in the other is one such thing you can't miss in a household with kids. Unhealthy snacking and lack o f physical exercise and fresh air causes obesity which endanger their lifespan. However, recent advancements in the field of modern gadgets does cause concern in the minds of the previous generation. The pods and loud music , generally used to De-stress, by teenagers causes serious hearing disorders. Decades ago, fun was about meeting up with friends and family over a social adhering, and now that children prefer chatting online to meeting up, parents do get a little worried.The worry ends up in reflecting badly on technological improvements. Besides, they overlook the fact that even they require gadgets to complete their daily tasks even as simple as sending an email and turn to youngsters to certain stuff they can't handle. Overall, rating technological advancements as a bane would be unfair to the present generation has it has so many positives to it. To wrap up my speech, would like to say a few words on how a rational use of technology could improve the outlook of children.Firs tly, to the parents who think advancements would prove to be a disadvantage to their children, I suggest they ensure the exposure is under their supervision and subtly handled. Secondly, technology is a limitless field of science where there is so much to learn and gather that, exposing our kids to it, would bring positive results as they would learn so much more. Speech Writing Read the following discussion and consider the views of both the teacher and her students. Write a speech for the school Science Club. In your speech ; describe some of the ways children use technology ; precautions children could take for health and safety ; views of older generations towards technology ; give your own views Base your speech on the ideas found in the discussion and be careful to use your own words. You should write between lo and 2 sides, allowing for the size of your handwriting.Up to ten marks are available for the content of your answer and up to fifteen marks for the quality Of your writing. After a Communication Studies lesson, the teacher, Mrs. Trapdoor, and three students discuss modern technology. Mrs. Trapdoor: That lesson makes me more worried than ever about your physical well being. Surely it's not a good thing that you use modern technology to escape from reality so often? Brat: So, what do you do to escape from the stresses of your job? No doubt you â €˜up the volume' on your classical music in the car or watch the latest soap opera on television.Either way, it's not that different. Mrs. Trapdoor: Okay, we all need to switch off now and then, but the kids see are permanently hooked up to some gadget that Stops them communicating with others. My son is constantly in his own bubble; if he's not on the phone to a friend then he's ‘shuffling' and focused on his music player, and don't get me started on these new games and films he watches on a ridiculously small screen. Catkin: It's the latest technology. It solves the problem of what film you all want to watch on television.He's just ‘zoning out'; its what we all do. In your day you would have gone to your room. Well, now we can block out situations hat are stressful. Mrs. Trapdoor: What? Like family life? You see that's what worries me. He's there in the room with us, but he's not really there. Ail: Well, it depends on how high the volume is! I can easily listen to m y music as well as tune in to what's being said around me. If my mother starts an argument, then I just turn the volume up to the maximum! Brat: That's how I like to listen to my music nanny. Loud.Mrs. Trapdoor: You see that also concerns me. New studies prove it is dangerous to listen to really loud music as it can cause hearing loss. [25] Catkin: Well, what about you and your laptop? You're always hunched over it typing, risking injury to your back and your hands. You see, you condemn our use of technology, but you forget how much people older than us rely on it. Plus, if anything goes wrong with your new devices, you usually ask us to fix it. Mrs. Trapdoor: Okay, I know you belong to the technological society, but it doesn't stop me worrying about your health.My laptop isn't a miniscule gadget that requires me to risk my eyesight to see the screen. The keys on your game players are so small that you could suffer from repetitive strain injury or even arthritis in the future. Catki n: get your point. However, we know that we should have breaks when our eyes get tired or our fingers ache. Mrs. Trapdoor: What about the dangers of walking around or cycling whilst the latest rap song is blaring in your ears? You're oblivious to the traffic around you and you risk being in an accident.What's more, someone could attack you as you wouldn't be aware of their presence. Ail: It is stupid to lock yourself up in your own world in a busy city, but is it very different from adult motorists talking on their mobiles and causing accidents? Mrs. Trapdoor: But it's in cities where I see most teenagers not interacting with hats going on around them, and they don't even mutter please or thank you to others who serve them. Ail: You can't blame these devices for bad manners. Don't tell me that adults aren't tempted to block out the noise and stress of public transport!I saw an old guy with headphones on in the subway, blissfully unaware of his surroundings. Mrs. Trapdoor: Everyone o ver thirty looks old to you lot! My point is still relevant. I'm not just concerned about noise. I've even heard of discos where teenagers listen and dance to their own choice of music on their own headphones. Catkin: Hey, that's a good idea! The world is changing. By the way, is that your cell phone ringing? A very warm welcome to one and all in the Science Club ! Does any one here know that technology could be dated back to the pre historic era?Well, before we get into that, lets define technology. As we all know , our lives revolve around technological advancements right from basic appliances like a fan or air conditioner to your Phone. Engineers all over the world strive to improve the quality of life, by inventing user friendly devices by which, life becomes comfortable. Who could say ‘NO' to ease and luxury in the fast advancing world Nicola Tests, the father of modern technology, as ridiculed by scientists then for inventing very important tools like the radio, Cray & the AC and DC motor.Some did not accept his theory, but least did they imagine, so many years later a life without these modern appliances. Technology should be encouraged when it comes to enriching a person's being. The very discovery of the ‘flint' stone is considered a technological advancement without which the discovery of fire would have been next to impossible. As the saying goes ‘Necessity is the mother of invention', the thirst and desire to learn and aspire is what drove cave man to improve his lifestyle. If only he did not do so, we would all remain in darkness till date.Since then, discoveries big or small have had a positive impact on the outlook of people and the way they choose to lead life. Not only has technology impacted the world towards fun and enjoyment, but also helped him have a larger life span , thanks to the advancements in the field Of healthcare. Technology alone has helped diagnose and treat life threatening diseases that could possibly wipe out our very existence on this planet. Hence, encouraging such endeavourers is an important step towards a healthy life. The past decade has seen profound increase in the use of entertainment technology by children, some as young as 1 year of age.It is hard to find kids who would prefer playing basket ball in the open to a SSP indoors. Doctors world wide believe , that ‘attachment' to technology has ‘detached' children from humanity as they would interact better with a Graphical User Interface than a fellow human being. Brain development research suggests that the frontal cortex of a child's brain is at risk where he looses impulse control and becomes more violent. Apart from this, the Electromagnetic radiations that are emitted from these gadgets are remarry causes of sensory and motor disorders in children.Being a couch potato , with a TV remote in one hand and a snack in the other is one such thing you can't miss in a household with kids. Unhealthy snacking and lack o f physical exercise and fresh air causes obesity which endanger their lifespan. However, recent advancements in the field of modern gadgets does cause concern in the minds of the previous generation. The pods and loud music , generally used to De-stress, by teenagers causes serious hearing disorders. Decades ago, fun was about meeting up with friends and family over a social adhering, and now that children prefer chatting online to meeting up, parents do get a little worried.The worry ends up in reflecting badly on technological improvements. Besides, they overlook the fact that even they require gadgets to complete their daily tasks even as simple as sending an email and turn to youngsters to certain stuff they can't handle. Overall, rating technological advancements as a bane would be unfair to the present generation has it has so many positives to it. To wrap up my speech, would like to say a few words on how a rational use of technology could improve the outlook of children.Firs tly, to the parents who think advancements would prove to be a disadvantage to their children, I suggest they ensure the exposure is under their supervision and subtly handled. Secondly, technology is a limitless field of science where there is so much to learn and gather that, exposing our kids to it, would bring positive results as they would learn so much more.

A Monster Cannot Be Created Essay

Do Humans have freewill or are they products of their environment? Everyone is different, everyone lives a different life, which factor cause a person to be the way they are nature or nurture? In Mary Shelly’s Frankenstein human nature causes Victor Frankenstein to become the real monster of the novel.  First of all let’s start out by analyzing Victor’s childhood. Victor came from a renowned family in Geneva. â€Å"I am by birth a Genevese, and my family is one of the most distinguished of that republic† (page 17). Also along with this he was born into a family full of love, in fact he was given almost all of the attention and love from his parents. â€Å"Much as they were attached to each other, they seemed to draw inexhaustible stores of affection from a very mine of love to bestow them upon me.† (page 19). So Nurture can not be held responsible for Victor’s monstrous persona, it must be because of nature. This shows that people have a predetermined personality, but this also shows certain parts of person’s personality can be reveled and or amplified due to changes in their environment. An example of this would be Alphonse Frankenstein’s disapproval of Victor’s scientific interests. Consequently forcing Victor into solitude, and revealing his obsessive tendencies. This is because Victor feels the need to measure the onward race for achievement against the yardstick of benefit to the human community. As a result of this human nature causes Victor to become a monster. Various factors influenced the development of Victor Frankenstein. For example, Victors unsupervised reading and education. This illustrates Victor’s natural obsession for knowledge. This shows the value of the human fulfillment of the pursuit of knowledge, and the importance of individual creative effort. Another example would be the immoral desertion of his creation. This shows that Victor cares little about anyone else’s interests and wellbeing. This is because Victor is extremely narcissistic and fails to assume responsibility for his relationship with others. Another case in point is the actual creation of a living human being. This shows that Victor has an innate passion for pushing the envelope of modern sciences. This helps illustrate the value of the need to measure the onward race for achievement against the yardstick of benefit to the human community. As a result Victor has a fascination for bending the laws of human nature. It seems a part of Victor’s personality goes into his creation. If you look closely at the novel you can see that there is a direct link between Victor Frankenstein and his monster, almost as if the two are doubles. For example, all of the murders Victor’s creation commits, could it be that Victor actually wants these people to be killed? Could Victor’s creation actually be another other side of him, much like a Dr. Jekyll and Mr. Hyde? â€Å"I considered the being whom I had cast among mankind, and endowed with the will and power to effect purposes of horror, such as the deed which he had now done, nearly in the light of my own vampire, my own spirit let loose from the grave, and forced to destroy all that was dear to me.† (page 61) Look at people that were murdered, Henry Clerval, Victor’s closest friend since childhood. He is Victors intellectual opposite, and quite possibly his rival for success. William, the more charming and spirited sibling, â€Å"when he smiles [William] two little dimples appear on each cheek, which are rosy with health. He has already had one or two little wives†¦Ã¢â‚¬  (page 56).  And what else could explain Victor’s judgment for not protecting Elizabeth from the monster. Victor is entirely aware that the monster will only kill the people close to him, and he is clearly warned that the monster will be with him on his wedding night, â€Å"It is well. I go; but remember, I shall be with you on your wedding-night.† (page 153 ). Does he tell Elizabeth, does he tell anyone what he knows? Absolutely not. The only time he tells anyone about his monster and its correlation with the murders is after everyone is already murdered. Coincidence? Some might argue that Victor’s creation is the real monster in the story because of free will. This is a valid argument but not necessarily true. Yes, it’s true that the monster had free will and that it was his decision to murder those people, but you have to understand the position the monster was in. He was abandoned by Victor as soon as he was created, and he was looked at as a hideous beast by anyone who laid eyes upon him. He was not given an equal opportunity to find acceptance among people because of his appearance, not because of his actions. An example of this is when he tries to save a young girl from drowning. He rescues the young girl, but as soon as someone else sees what is happening he automatically assumes that he is trying to murder the young girl. â€Å"The whole village was mused; some fled, some attacked me, until, grievously bruised by stones and many other kinds of missile weapons, I escaped to the open country, and fearfully took refuge in a low hovel, quite bare, and making a wretched appearance after the palaces I had beheld in the village.† (page 91). What people forget is that the monster was created by Victor which is not a natural occurrence; therefore the rules of nature do not apply to him. The monster is the way he is because of how Victor created him. The only difference between the two is that the creation was not accepted in his environment, thus bringing out a hidden persona.  A monster can not just be created; a monster comes from within the creator, and in the end Victor’s creation becomes his death. â€Å"Blasted as thou wert, my agony was still superior to thine; for the bitter sting of remorse will not cease to rankle in my wounds until death shall close them for ever.† (page 205).

Diary Entries Essay Example | Topics and Well Written Essays - 750 words

Diary Entries - Essay Example I continue thinking about my psychiatrist, which is even after he denies the fact that I need one. I contend that the psychiatrist wants to find out the reason why I hike in the forests, while collecting butterflies and watching birds and I intend to show my collection to him one (Bradbury, 23). Most of what I do is considered as strange by other people even when, for my time, it seems normal. That I need a psychiatrist is crazy, particularly since I do the same things that other people do. I ask Montag concerning his firefighting job, stating that he is very different from other firefighters I know because he is attentive to what I tell him, and actually, tries them out. I go on to tell him that he is one of the few persons who stand (Bradbury, 23). It seems that most of the people that I am in contact with are always fast paced, and Montag is no different. I think that Montag does not have time to notice the dew that had settled on the grass in the morning. For instance, it is up t o me to tell him that there is dew on the grass that morning and every morning. Suddenly, I notice that he does not seem to remember whether he had ever noticed the dew and this makes him very irritable. I have always noticed most small things that others cannot, which makes me very observant. After I pester Montag with various questions, he surprises me by telling me that I had better run on to the (Bradbury, 24). I obey him, and see him tilt his head back into the rain, open his mouth for a few minutes, and catch the falling drops of rain just as I had been doing when they met. I also notice that Montag seems curious regarding the things that I am doing because he is always attempting to do the things that I ask him to do. Diary entry #2: Montag I meet Clarisse McClellan, who is my new and vivacious young neighbor and I just seem to begin questioning whether I am happy. She gives me enlightenment, as she asks me questions on my own individual happiness, as well as his occupation a nd the fact that I do not seem to know much concerning history (Bloom 16). Clarisse, through the little things she does, also gives the opportunity for me to see dramatic changes within the government regarding the perception of citizens about their history. For instance, I had no idea that the real work of firefighters entailed fighting to put off real fire, or even that billboards only stand at twenty feet in height. In addition, I also had no idea that people had the ability to actually speak to each other. This is because the use of parlor walls by the government had removed any requirement for causal conversation (Bloom 16). Clarisse arouses the curiosity in me as she begins to aid me in the discovery of the fact that I have been missing real happiness in my life for a long time. After I meet the young girl Clarisse, I go back to the house and find that my wife is lying on the bed, unconscious. She has her Seashell radios close to her head and I find that she has overdosed on s leeping pills, as well as tranquilizers (Bloom 18). Her life is saved after two technicians, who I find very impersonal; bring machines that aid then in removing the drugs from her belly, while also giving her a complete transfusion. However, I believe that it is possible she will overdose again with no knowledge of what she was doing. While it is my wish to discuss the overdose,

Low carb better than low fat to prevent cardiac disease Assignment

Low carb better than low fat to prevent cardiac disease - Assignment Example ed, parallel-group trial with the aim of examining the effects of low-carbohydrate in comparison to the effects of a low-fat diet on body weight and CVD" (Bazzano et al., 2014, p. 308). The participants included representatives of all populations and observation were made for a period of twelve months. In the previous studies either the participants failed to complete the study, had low participation, involved small size, failed to examine the effect of low-carbohydrate on weight reduction or did not take into consideration the population diversity. However, the present clinical trial involved examination of the effect of low-carbohydrate diets on weight loss, included black members that were previously ignored and had high completion rate of eighty percent and the sample size relatively bigger (Bazzano et al., 2014). Therefore, the outcome of the investigation was more accurate and convincing. Consumption of diet with low-carbohydrate results to a reduction of weight and CVD risk factors compared to low-fat diets. The low-carbon and low-fat diets use contribute to decline of plasma glucose, blood sugar, creatinine and serum insulin levels in an uniform fashion among the diverse population of the participants (Bazzano et al., 2014). Therefore, persons intending to lose weight or reduce CVD risk factors can decide to consume a diet with low-carbohydrate as opposed to low-fat diets. Furthermore, the policy makers can plan on policy intervention applicable to diverse groups in the United States as opposed to using of different policies for various groups since similar foods have same effects on diverse populations. The study is of significance to the research centers because it has increased knowledge about effects of low-carbohydrate and low-fat diets on reduction of weight and CVD risk factors. The health caregivers can comfortably recommend the use of low-carbohydrate diet s to people with obesity for reducing weight and CVD risk factors There has been a major

Interview with James Article Example | Topics and Well Written Essays - 500 words

Interview with James - Article Example Based on quantitative investment, James values the following; It is indispensable that for any investor to do stock evaluation before investing in business. Empirically stock sometimes may be favorable or unfavorable but it is essential to note that as much as you pay less you gain more in the end. However, the contrary of paying more and getting less in the end may discourage within the stock market. In performing any stock evaluation an individual need to have an exceptional and competent foundation in mathematics. For instance, James learnt econ-metric that advantaged him within the profession (OShaughnessy and Ritholtz 11:20). As much as Asset management may seem easy with the use of models, it is important to note that they do not often work. What any individual need is to understand the concept to successful manage the asset successfully (OShaughnessy and Ritholtz 14:01). It is clear that the society survives in a typically economical challenging period. Everyone wants to have high dividend returns. This may be an over value thus it is vital to examine overseas markets beyond U.S. This will ensure better returns. Other markets such as Europe and Asia may provide the better returns compared to the local big U.S stock firms. Other low rated stocks can be a good investment if an investor look a horizon of let say 10 years and beyond as they can be more stable thus more returns (OShaughnessy and Ritholtz 21:00). Many will try to shy off the emerging markets due to its uncertainty in their stock returns. The fact is that they are the powerhouse of GDP as they contribute about 50 percent of the U.S GDP. However, it is advisable to note that with a long run venture such as 10 years emerging markets are the best for investment. Many investors may forego this fact but the truth is with the correct mathematics before investing

Gathering instruments Essay Example | Topics and Well Written Essays - 1000 words

Gathering instruments - Essay Example Test results Interview on Increased wait-time effectiveness Teacher Tallying worksheet Teacher assessment in comparison with wait-time journaling The research will have four data sources that will be used to gather for the analysis of the experiment based on the question: What are the effects of increased wait time on the quantity of correct responses from elementary ELL students in a classroom? Data collection process is simple for the clients to comprehend following that the interview will be based on set answers, for example, a student will have to choose one option provided in the questionnaire. The first technique of gathering data will be the results obtained from the test that will be used to show the effect of increased wait-time on students. The test will have distributed grade 5 questions of different subjects including mathematics, Biology, English and Science. This test will have questions that require different cognitive levels. The researcher will then record the number of correct and incorrect responses from each of the ELL students. The test result will provide analysis on correct answers prior to increasing wait-time and after when the wait-time is increased depending on the cognitive level of the questions. The test will have 50 questions of which 10 will be read to the students for one week with normal wait-time and then a repeat of the trend for the next one week with increased wait-time . The researcher will use the test to find out whether increased wait-time has an effect on the quantity of correct responses from the two ELL students. Secondly, the researcher will conduct an interview that will be transformed into a percentile pie chart to indicate how normal wait-time (session #1) and increased wait-time (session #2) affects the quantity of correct responses from the two ELL students. For two weeks, the students will be requested to select a session, which provided sufficient time for critical thinking in giving correct responses. The re searcher will tally the interview responses to see the change in the trend of correct responses given by students. The two sessions will be formulated into a chart that will indicate the effect on the quantity of correct responses after increased wait-time is implemented. The third data collection technique will be a teachers tally on the number of correct response from the student. The quantity of correct responses after increasing wait-time will be tabulated in a table against a table that will be indicating the number of correct responses prior to increased wait-time. The table will be then analyzed used mathematical formulae to determine to determine the effect on correct responses after the implementation of increased wait-time. Lastly, the final data source will be an assessment of the responses given by the students. The researcher will assess every response given by the students in comparison with the wait-time allowed for every question. This will also include behavior asse ssment on the willingness of a student to give a response that directly affects the nature of the response, either correct or incorrect. Additionally, the researcher will analyze the effect of increased wait-time on a student’s cognitive level in responding to various questions. In conclusion, the four data sources will provide accurate data that will be analyzed collectively to

Design a Pay for Performance Incentive Awards Program Assignment

Design a Pay for Performance Incentive Awards Program - Assignment Example program that will run for five years within the organization seeks to maximize productivity besides developing an appropriate mindset among the employees. This way, the program is not only a short-term project but also a long-term motivational project. As discussed, the program will incorporate all the employees within the company including the top-level managers to the junior employees. In order to implement the program appropriately, the implementation will therefore vary depending on the employees. Just as the title suggests, the program seeks to reward productivity. Each level of employee has specific goals that the program will strive to achieve. In the top-level management for example, the program seeks to enhance creativity, intuition and management prowess. In middle level management, the program seeks to enhance both obedience and problem solving skills while in the junior employees of the organization the program seeks to enhance both competition and hard work. This way, the program enhances the overall productivity of the entire organization. Preliminarily, the program will ensure that all the employees within the organization are capable of undertaking their different roles. This complements the objective of the program since it seeks to reward productivity. The employees must therefore meet the qualifications set for their different roles a feature that ensures that they are capable of undertaking their roles within the organization. Furthermore, qualifications ensure that the employees are capable of meeting the obligations of their respective positions besides enhancing the ease of management. Top-level management must have appropriate qualifications. Managers make decisions daily operations within the organization through the formulation and implementation of policies. As such, they must have both the appropriate education and professional training to enable them make such appropriate decisions. The performance reward program will acknowledge the

Boosting employee morale Essay Example | Topics and Well Written Essays - 250 words

Boosting employee morale - Essay Example To test whether the skills or methods used in the process increases employee morale, the first step is to identify the variables involved. These could be qualitative or quantitative in nature (Johnson 304). The impact of increased employee morale can be quantitative, but the skills or methods applied are highly qualitative. To test the impact that skills or methods used create in boosting employee morale, quantifying skills/methods variables is vital. ANOVA tests suit this process (Johnson 357). Once the qualitative variables are quantified, they can be linked to the outcome of increased employee morale through the necessary testing steps in ANOVA statistical procedures. Achieving the above goal can be subject to a number of issues that influence the inferences made from the test. These are: difficulties in choosing the quantitative variable to use following improved employee morale (for example increased output or revenues), individual differences across employees may not be accounted for, and quantifying some qualitative variables of skills/methods nature may result in a totally different outcome. On the other hand, the testing design adopted exhibits both strengths and weaknesses. The quantification of qualitative variables makes the testing process quick and easier (Johnson 391). However, the testing procedure may be prone to statistical errors that may result in conclusive inferences that are rather

Assignment. Product deelopment Assignment Example | Topics and Well Written Essays - 750 words

. Product deelopment - Assignment Example The companies are retailers in freshly brewed coffee and are using status/prestige pricing, market penetration pricing, and market pricing strategy. They include Starbucks, McDonald’s, and Dunkin’ Donuts respectively1. Status/prestige involves setting prices higher than the competition in order to create a perception of an added advantage of the product that creates a reputational quality and distinction. Market penetration pricing involves offering a product/service at a lower price to attract customers from those offering the same product at a higher price. On the other hand, market strategies considers various things before setting the price, but mainly evaluating prices of similar products in the market. It can set prices higher than the competition if it deems it has more features or less if the features are less. Starbucks has been a master of employing value-based pricing to maximize profits. It does this by using research and customer analysis to formulate targeted price increases that capture the greatest amount consumers can will to pay without driving them off. The company does profit maximization by determining the price and product output level that generates most profit2. As has been implied through market penetration strategy, McDonald’s is after the mass market by offering lowest, on average, prices compared to the other two. This strategy is intended to create traffic large enough to cover all cost incurred, including selling cheaply per latte. Lastly, Dunkin’ Donuts prices its products in comparison to the two (market strategy) by offering similar-featured coffee to that of Starbucks and better than McDonald’s3. By using this strategy, its hopes to undercut and win Starbucks’ customers for the same features and offer better features to McDonald’ s customers, hence enough margin. The three coffee shops have different minimum order quantity (MOQ) that will enable each to make reach their marginal

RACE, ETHNICITY, AND CRIMINAL JUSTICE Research Paper

RACE, ETHNICITY, AND CRIMINAL JUSTICE - Research Paper Example As a result of these types of labels, these people were instantly placed on a significantly lower social level than the Europeans within the minds of the Europeans who eventually gained dominance. This mindset lives on today in the European-styled society we perpetuated. Overt discriminatory practices during all phases of the criminal justice system concerning ethnic minorities, especially those of African-American or Hispanic descent, have been well-documented. The recently increased implementation of law enforcement measures which are exclusively aimed at minorities and immigrants through tactics such as racial profiling have exacerbated long standing tensions with police agencies. These interactions are becoming increasingly tense as evidenced by a proliferation of physical and verbal abuse towards minorities and immigrants, a growing mutual distrust and an escalating threat of violence. Of course, crime can occur in fully homogenized societies and a tendency to commit crimes in i mpoverished areas is understood to be the result of economic rather than racial issues. However, racist perceptions are reflected in laws, traditions, and hiring practices causing minorities to be disproportionately represented in depressed neighborhoods. This is a rather obvious explanation for social injustice creating crime. An additional reason could be that because minorities are targeted as potential criminals, it is generally perceived by the majority that simply being a minority places the individual under suspicion. The U.S. incarcerates more of its population per capita than any other industrialized country. Currently, more than two million prisoners are jailed in local, state or federal facilities. It is not just the number of prisoners that is increasing, but the ratio of prisoner to free population is widening as well. Approximately 10 years ago, there were about 703 prisoners in every

Violence in Mexico Essay Example for Free

Violence in Mexico Essay Nothing is surprising today that many today’s newspapers articles, publicized about how elderly people around the world had been discriminated, especially in Mexico. These older people gave us life, they are harmless, defenseless, some society members see them as an obstacle, also a heavy load that need to be carry on their backs. They are jeopardizing their life because of the way society treats them and because of the actual violence in Mexico. There are 600 million elderly people in the world; seven of them living in Mexico, according to the INEGI (Mexico’s census) showed statistics that elderly population is living longer and their population is increasing. Doctors and medicines can reach now the rural areas where before was impossible to get medical aid, also better medicines had being discovered and doctors are getting better preparation than before. The welfare of the elderly population has numerous dimensions, poverty, health care, and the receipt of pension income. In Mexico, many benefits such as having access to health care and receiving a pension at old age are associated with a form of employment. Since women historically have participated less in the labor market than men have, it is natural to expect that women would experience lower living conditions than men would in old age; also the wellbeing of the elderly group is dramatically inferior comparing to other age groups. Fewer older parents wish to assume the uncertainties of following their children across international borders, especially if they or their children have no legal documents. Instead, older people tend not to move, and sending areas often become old as the young migrate and leave their parents and grandparents behind. Mexico’s large population has a high level of poverty and hunger compared to rest of the world. Migration is a fluid process, however one that not only influences social behavior in U.S. destinations, but also lives and lifestyles across the border in Mexico. Although we might hear more about immigrants living and working in United States cities, the vast majority of Mexican immigrants and/or their families do not move to the United States permanently. In fact, Mexico-United States migration most commonly involves individuals leaving their households to engage in temporary or recurrent United States migration strategies that are identify by short-term stays and repeat trips. Two emerging from this social process are transnational communities, involving spatial, economic, and social ties that link residents between the two countries. Some elderly parents will look to their children for support, but some will find a limited set of alternatives given the prevalence of migration. Thus, migration may cause a rise in the number of elderly living alone or seeking alternative types of living arrangements to meet their needs. The discussion below first describes traditional patterns of living arrangements and intergenerational support in Mexico; then examines migration patterns and begins to assess their consequences for elderly living arrangements; and finally presents findings from data collected in fifty-two Mexican villages. No one, especially not one of Mexicos top law enforcement officials, denies that killings by drug cartels have reached record levels. Mexico all of a sudden stopped being a drug-transit country and became a drug-consuming country this means gangs that once shipped drugs into the United States, are now fighting each other to sell the drugs at home. Their fights center on territory whose gets to sell what and where. The only way to settle their differences is through violence, Rubido said. Theyre fighting block by block in a very violent way. The result is a brutal onslaught that resulted in about fifty-four thousand deaths last year, more than double the tallied in 2007. Many analysts say Mexico is on track to set a record again this year. A United Nations report released this week notes that the government of Mexico faces violent opposition by drug cartels to its attempts to fight organized crime and drug trafficking, adding that drug cartels have responded with unprecedented violenc e. That intimidation can often take brutal forms. Last weekend, a police official from the state of Tabasco, arrested a dangerous and one of the country most wanted drug trafficker, a week later he was killed so were his mother, his wife, his children, nieces and nephews. Twelve people total were dead in three homes. Six of them were children. While drugs are being smuggled north, a lot of guns are going south, said Brian Jenkins, a terrorism expert at Rand Corp. â€Å"Authority does not have control over all of its national territory and they had lost most of it to traffickers.† President Felipe Calderon criticized the media for mounting a campaign of â€Å"lies† against Mexico. His comments come two days after important French politicians visited this country, U.S. Director of National Intelligence, said Mexico is not in charge of parts of the country. It pains me the way elderly people is suffering, their only goal is to achieve peace and love, they already gave these to us, now is time to pay them back, we as their descendants should look for the opportunity to share happy moments with them, and place them in places where they are going to be safe and happy.

Low-grade Rhabdoid Meningioma: Morphological Characteristics

Low-grade Rhabdoid Meningioma: Morphological Characteristics Arvids Jakovlevs, Andrejs Vanags, Janis Gardovskis, Ilze Strumfa SUMMARY Rhabdoid meningioma (RM) is a rare type of meningioma. It is classified as a grade III tumour (anaplastic meningioma) in the recent World Health Organization (WHO) classification of the tumours of the central nervous system (CNS). Here we describe a unique case of RM lacking any features of malignancy. Few cases of low-grade RMs are described in the literature in contrast with the grading of this entity in WHO classification. Key words: meningioma, rhabdoid, low-grade AIM OF THE DEMONSTRATION The aim of our article is to report a case of unusual RM lacking malignant features in regard to the issue about the prognostic significance of rhabdoid morphology in meningiomas. CASE REPORT A 37-year-old woman was admitted to the hospital due to progressive headaches over previous 1.5 years. The magnetic resonance imaging of head and brain revealed a well-demarcated intracranial lesion measuring 3.53.63.6 cm (Figure 1A). The mass was located adjacent to the frontal bone and was attached to the dura mater. The patient underwent a craniotomy and total tumour resection. Histological examination of the neoplasm revealed cells consistent with rhabdoid morphology. The tumour was almost entirely composed of polygonal, rather large cells that possessed eccentric nuclei, strongly eosinophilic cytoplasm with abundant pale globular inclusions and prominent cytoplasmic granularity (Figure 1B). The nuclei of neoplastic cells were slightly pleomorphic. Mitoses were absent in the whole specimen. In addition, the tumour had well-developed fibrous capsule that demarcated it from normal brain tissues. Psammoma bodies were found in some areas of the tumour. Immunohistochemical visualizati on (IHC) showed intense cytoplasmic expression of vimentin and epithelial membrane antigen (Figure 1C-D) as well as strong nuclear expression of progesterone receptors in the tumour cells. The neoplastic cells did not express smooth muscle actin, desmin, HMB-45, S-100 protein, kappa and lambda light chains. Ki-67 proliferation index was as low as 1.5 %. Thus, the morphological appearance and immunohistochemical features were consistent with RM and low-grade cellular characteristics. DISCUSSION Tumours with rhabdoid morphology were first described in 1978 in relation to malignant renal tumours of children (1). Nowadays, many tumours with rhabdoid morphology are known in different localizations including CNS and meninges. Rhabdoid cells have no evidence of myogenic origin. The term „rhabdoid† is used to denote close histological resemblance of tumour cells to rhabdomyoblasts. Rhabdoid cells are characterized by typical light microscopic morphology: round cells with eccentric, vesicular nuclei, prominent nucleoli and eosinophilic cytoplasm with paranuclear globular inclusions (3). Meningiomas developing from the meninges are among the most common intracranial tumours. Regarding these tumours, surgery is the mainstay of treatment, and neurosurgeon also is involved in the planning of further observation and treatment in accordance to the tumour grade (5). Meningiomas show wide range of histopathological appearances. While the majority of meningiomas are benign tumours (WHO grade I meningiomas), some meningiomas have increased risk of local recurrences (WHO grade II meningiomas) and the minority are truly malignant and have a risk of metastatic dissemination; these are classified as WHO grade III meningiomas (2). RM is an uncommon type of meningioma which was described for the first time in 1998 (3). It was found that rhabdoid morphology in meningiomas was associated with a worse prognosis (3). Soon after this finding RM was separated as a distinct entity in WHO classification of CNS tumours published in 2000. RM has been classified as a grade III neoplasm by WHO (2). Consistent with the malignant behaviour, significant mitotic activity, anaplasia and other atypical features are usually found in RMs (2, 4). However, there are some isolated reports of RMs with no evidence of cellular atypia (6). In our case diagnosis of RM was established due to pure rhabdoid morphology along with meningothelial origin that was clearly demonstrated by IHC. Absence of atypia in the tumour cells and low Ki-67 proliferation index was consistent with low-grade meningioma in the present case. In conclusion, rhabdoid meningioma occasionally lacks histological features of malignancy that can lead to confusion if the rhabdoid morphology is always associated with malignant behaviour. Increased awareness of low-grade rhabdoid meningiomas is necessary to estimate the prognosis and to plan the treatment appropriately. REFERENCES Beckwith JB, Palmer NF. Histopathology and prognosis of Wilms tumors: results from the First National Wilms’ Tumor Study // Cancer, 1978; 41:1937 – 1948 Cooper WA, Shingde M, Lee VK, Allan RS, Wills EJ, Harper C. â€Å"Rhabdoid meningioma† lacking malignant features. Report of two cases // Clin Neuropathol, 2004; 23(1):16 – 20 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. Meningeal tumors // In: Bosman FT, Jaffe ES, Lakhani RS, Ohgaki H. WHO Classification of tumours of the central nervous system. 4th edition. Lyon: IARC; 2007; 164-180 Perry A, Scheithauer BW, Stafford SL, Abell-Aleff PC, Meyer FB. Rhabdoid meningioma: an aggressive variant // Am J Surg Pathol, 1998; 22:1482 – 1490 Walcott BP, Nahed BV, Brastianos PK, Loeffler JS. Radiation treatment for WHO grade II and III meningiomas // Front Oncol, 2013; 3:227, doi:10.3389/fonc.2013.00227 Zhou Y, Xie Q, Gong Y, Mao Y, Zhong P, Che X, Jiang C, Huang F, Zheng K, Li S, Gu Y, Bao W, Yang B, Wu J, Wang Y, Chen H, Xie L, Zheng M, Tang H. Clinicopathological analysis of rhabdoid meningiomas: Report of 12 cases and a systematic review of the literature // World Neurosurg, 2013; 79(5-6):724 – 732 3t-Alkyl-2r,6c-diarylpiperidin-4-ones: Synthesis 3t-Alkyl-2r,6c-diarylpiperidin-4-ones: Synthesis 3t-Alkyl-2r,6c-diarylpiperidin-4-ones Synthesis A very convenient and non-laborious one-pot synthesis method developed by Noller and Baliah [50] has been used successfully for the synthesis of 3t-alkyl-2r, 6c-diarylpiperidin-4-ones 32 by the condensation of methyl ketones, aromatic aldehydes and ammonium acetate in 1:2:1 molar ratio (Scheme 13). It’s a non-laborious one-pot synthesis of 3t-alkyl-2r, 6c-diarylpiperidin-4-ones 32. Various substituted piperidin-4-ones were also synthesized by adapting the above method [53-,57]. Often used typical procedure reported by Baliah and Jeyaraman was adapted to synthesis several substituted 3t-alkyl-2r,6c-difuranylpiperidin-4-ones 33 and 3t-benzyl-2r,6c-diarylpiperidin-4-ones 34 with convenient modification [58,59]. Seven r(2),c(4)-bis(isopropoxycarbonyl)-t(3)-aryl-c(5)-hydroxy-t(5)-methylcyclohexano-nes (aryl = C6H5, p-ClC6H4, p-FC6H4, p-OMeC6H4, p-Me2NC6H4, m-O2NC6H4 and m-C6H5OC6H4) have been synthesized by condensing isopropyl acetoacetate with aromatic aldehydes in the presence of methylamine [53]. Aridoss et al have synthesized an array of novel N-morpholinoacetyl-2,6-diarylpiperidin-4-ones as well as imidazo(4,5-b) pyridinylethoxypiperidones and Structure and stereochemistry of all the N-morpholinoacetyl-2,6-diarylpiperidin-4-ones have been analyzed using 1H and 13C NMR spectroscopic techniques [54,55]. 1H and 13C NMR spectra have been recorded for 2r,6c-diarylpiperidin-4-one (3_-hydroxy-2_naphthoyl)hydrazones and 3,3-dimethyl-2r,6c-bis(p-methoxyphenyl)piperidin-4-one [56-57]. Conversion to other derivatives Other derivatives from piperidin-4-ones have been obtained which includes oximes 35 [60-73], hydrazones 36 [57,74], semicarbazones 37 [75], thiosemicarbazones 38 [69], and phenylhydrazones 39 [76] by the reaction of the carbonyl group with suitable reagents. 2r,6c-diarylpiperidin-4-ones have been reduced to obtain 4t-Hydroxy-2r, 6c-diphenylpiperidines 40a and 4c-hydroxy-2r,6c-diphenylpiperidines 40b. N-substituted 2r,6c-diarylpiperidin-4-ones 41-51 was obtained by the reaction of the NH function with suitable reagents have been reported (Scheme 13) [77-84]. Physico-chemical studies Several physico-chemical studies have been performed for 3t-Alkyl-2r,6c-diarylpiperidin-4-ones and their derivatives [64-91]. Several studies have documented the conformations of various substituted 2,6-diarylpiperidin-4-ones [78,86]. Pandiarajan et al. [88] have elaborately discussed the conformations of 32 and suggested chair conformation to these compounds with equatorial disposition of the aryl and alkyl substituents based on their NMR spectral data. Substitution of alkyl group at C-3 position of the piperidine ring causes the ring to flatten slightly about C(2)-C(3) bond probably to decrease gauche interaction between aryl and alkyl groups at C(2) and C(3). Stereochemistry of N-acetyl and N-benzoyl-2r,6c-diphenylpiperidin-4-one oximes 5256 has been already reported [89]. Synthesis and conformation of 3t-chloro-2r,6c-diarylpiperidin-4-ones 57 also been reported [90,91]. Manimekalai et al. [92] demonstrated the conformation of benzyl group in 4-benzyl-4-hydroxypiperidines 58. Pharmacological studies Many piperidine derivatives possess pharmacological activities including antimicrobial, antioxidant and anticancer activities and to form an essential part of the molecular structure of important drugs [9, 93-97]. Piperidin-4-ones have been used for development of compounds with selective biological activities include antiviral [98], antitumor [99], analgesic [100], local anesthetic [101,102], bactericidal [103], fungicidal [103], herbicidal [103], insecticidal [104], antihistaminic [104], anti-inflammatory [104], anticancer [105], CNS stimulant [105], antitubercular and depressant [106] activities. Earlier reports have clearly established that the biological activities[R1] of piperidin-4-ones were improved by incorporation of the substituents at C-2, C-3 and C-6 [106,107]. Ferguson documented that N-nitrosopiperidines are carcinogenic in nature and blocking of one of the à ¯Ã‚ Ã‚ ¡ position by an alkyl group significantly reduces the carcinogenic activity [108]. Lijinsky and Taylo r have also supports that blocking of à ¯Ã‚ Ã‚ ¡ positions to the N-nitroso group by methyl groups reduces the carcinogenic activity [109]. 3t,5t-Dimethyl-2r,6c-diarylpiperidin-4-one hydrochlorides 59-61 have shown anti-histaminic activity [110]. Furthermore, 3t,5t-dimethyl-2r,6c-bis(4-hydroxyphenyl)piperidin-4-one 62 and 3t-methyl-5-substitutedphenyl-2r,6c-diarylpiperidin-4-ones 63 showed antimicrobial, insecticidal and antihistaminic activities [111]. 2,3,6-Triarylpiperidin-4-ones 64 and their oximes exhibits marked bactericidal, fungicidal and herbicidal activities [104]. N-Substituted piperidin-4-one 65 and its derivatives 66 and 67 exhibited potential Juvenile hormone activity on Bombyx mori [112]. N-methyl-3E,5E-bis(arylidine)piperidin- 4-ones 68, possessing a variety of aryl and heteroaryl groups, showed antiviral and antitumor activities [98]. 3E,5E-Bis(benzylidene)piperidin-4-one 69, 1-acryloyl derivatives of 69, and 70 the adduct of 2-mercaptoethanesulfonic acid 71 as well as 3E,5E-Bis(thienylidene)-piperidin-4-ones 72 have shown antitumor activity towards human carcinoma cell lines Caov3, Scov3 and A549 [113]. Furthermore, modification of position 3 of the piperidin-4-one nucleus as well as a substitution of certain functional groups in the para position of phenyl ring attached to C-2 and C-6 carbons of the piperidine moiety would result in compounds of potent biological activities. Hydrazones Hydrazones are a class of organic compounds with azomethine -NHN=CH- proton that constitutes an important class of compounds for new drug development [10,97,98]. Hydrazone are formed usually by the action of hydrazine on ketones or aldehydes. Hydrazide-hydrazone derivatives receive the attention of various medicinal chemists as a result of their effectual biological potencies viz., antimicrobial, anti-tubercular, and also anticonvulsant actions [10,114-116]. Some hydrazones is known to act as herbicides, insecticides, nematocides, rodenticides and plant growth regulators. Several studies have documented the spasmolytic activity, hypotensive action and activity against leukaemia, sarcomas and other malignant neoplasms [114-116]. Many of the physiologically active hydrazones have applications in diseases like tuberculosis, leprosy and mental disorder are characterized by the presence of the triatomic group (>C=N–N73 [117]. Hydrazones are also useful in detection, determination and isolation of compounds containing the carbonyl group and many other metals [10]. Syringaldehyde hydrazones 74 and 6-nitro-3,4-methylene-dioxophenyl-N-acylhydrazone 75 exhibits antioxidant properties [118,119]. Hydrazone and its substituted derivatives showed good antibacterial, antifungal, anticonvulsant, antitubercular, anticancer and antitumor activities. 1-[4=[(2-[(4-Substitutedphenyl)methylene]hydrazine] carbonyl)phenyl]-3-substituted thioureas 76 exhibited good clinically active tuberculostat [120]. Some coupling products from 4-aminobenzoic acid hydrazones 77 and (7-Hydroxy-2-oxo-2H-chromen-4-yl)acetic hydrazide 78 showed antimicrobial activity [121,122]. A series of 4-fluorobenzoic acid (substituted methylene/ ethylidine) hydrazide derivatives 79 showed the chemotherapeutic antituberculosis activities [123]. Hemalatha et al have documented the antibacterial and antifungal activities of N-nitroso-2,6-diarylpiperidin-4-one semicarbazones [124]. Some bicyclic semicarbazones and thiosemicarbazones 81 showed a wide variety of biological activities [124]. The significance of fusing heterocycles Heterocycles possess an enormously diverse group of compounds, are widely distributed in nature. Heterocycles can be easily manipulated and modified by organic synthetic methods to increase or decrease reactivity. They are used extensively as intermediates in various reactions as well as building blocks in organic synthesis. Novel libraries of biologically diverse heterocyclic compounds have been synthesized by incorporation and substitution of a wide range of functional groups (ring activators or deactivators) and their positions around the ring of heterocycles. Several studies provide evidence that combination of two bio-active heterocyclic moieties together leads to the production of novel and biologically important compounds with the anticipation of several promising pharmacological agents [4,125]. Based on the above features discussed under 3t-Alkyl-2r,6c-diarylpiperidin-4-ones, 2r,4c-Diaryl-3-azabicyclo[3.3.1]nonan-9-ones and hydrazones, we have developed the system that fuse 3 -azabicyclonones/piperidin-4-one pharmacophore and hydrazide moieties together to produce the corresponding hydrazones with the anticipation of several promising antioxidant, anticancer and antimicrobial agents arising. The relevant technique used to elucidate the structure of the newly synthesized compounds Specialized spectroscopic instruments can be used to generate information that enables the determination of the structure of an unknown organic compound. This includes Infrared spectrometry (IR), nuclear magnetic spectrometry (NMR) and elemental analysis. Among all available spectrometric methods, NMR is the only technique which offers a complete analysis and interpretation of the entire spectrum [126,127]. A few of the strategies of NMR experiments that are used in determination of different compounds are described as follows. NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY Nuclear magnetic resonance spectroscopy, one of the most versatile techniques for elucidation of structure of organic compounds, has shown a tremendous progress due to improved experimental technology and novel approaches. In NMR, the most useful information comes from the interactions between two nuclei, either through the bonds which connect them (J-coupling interaction) or directly through space (NOE interaction) [126-128]. Interpretation of NMR spectra is well understood from the following basic information gathered from NMR spectra. 1) Chemical shift, which identifies the type of proton based on their electronic environment, 2) Spin-Spin splitting patterns, which identifies neighbouring protons, 3) Peak Area, which is proportional to the number of protons giving a particular resonance line, 4) The observation of a triplet and a quartet spin state confirming usually the presence of an ethyl group (CH3CH2) and 5) The observation of ÃŽ ´ values between 7.2-8.0 indicates that the structure contains a benzene ring (benzyl proton) [126-130]. Generally, three approaches are used in NMR spectroscopy methods. These include one dimension (1D), two dimensions (2D) and three dimensions (3D). The first approach of 1D-NMR (1H DEPT, 13C, 15N, 19F, 31P, etc.) generates good information about the structure of simple organic compounds. However, it is overcrowded in case e of larger molecules. The second approach of 2D-NMR (COSY, DQFCOSY, MQFCOSY, HETCOR, HSQC, HMQC, HMBC, TOCSY, NOESY, EXSY, etc.) is used for the further larger molecules. A 2D-NMR spectrum also becomes complex and overlapping in case of further very large molecules like proteins. Therefore, multi-Dimensional-NMR (Homonuclear and Heteronuclear) are generally used to achieve high resolution and reduced overlapping in spectra of very large molecules [126,128,129]. This section further describes the general interpretation of structure of different organic compounds by different NMR techniques. 1D NMR SPECTROSCOPY 1H-NMR: Spin transitions of only hydrogen nuclei are observed in in 1H-NMR spectroscopy. Table 1 represents different ÃŽ ´ values, couplings, coupling constants and chemical shifts of 1H nuclei processing in different chemical environments. Commonly, ÃŽ ´ value scale of 1H-NMR ranges from 0-10 ppm with respect to Tetra methyl Silane (TMS) as internal standard. 1H-NMR spectral interpretation can be best understood from table 4 [126,131]. 1H Chemical shifts Because of variations in the electron distribution, the variation of nuclear magnetic resonance frequencies of the same kind of nucleus is referred to as chemical shift (symbolized by ÃŽ ´). Quantitative chemical shift are measured in frequency (Hertz) relative to a standard, Tetra methyl silane (TMS). Characterization of the structure of a molecule is depending upon the position and number of chemical shifts [111,112,115]. The chemical shift range of 1H nuclei can also be understood from a chart given in figure 1 [126].The chemical shift values for methyl protons attached to groups of varied electronegativity are given below [127]: CH3I-2.16 CH3Br-2.18 CH3Cl-3.05 and CH3F-4.26 ppm, The electron density around the proton affects its chemical shift. Because of the e- density around the H nuclei, the CH3 protons come to resonance at higher ÏÆ' values as the electronegativity of a functional group is increased. Electronic charge surrounded to H nuclei shields the nucleus to some extent from the influence of the applied field. The magnetic flux overcomes this shielding effect in order to bring a proton to resonance. Thus, the higher the electron density around the proton, the greater the induced diamagnetic effect and the greater the external field required to overcome the shielding effect. Electro-ve groups like fluorine in CH3F withdraws e- density from the CH3 group (-inductive effect). This leads to de-shielding by lower value of an applied magnetic field in order bring the methyl proton to resonance. Fluorine is more electro-ve than Cl, thus the proton in CH3F appears at a higher ÃŽ ´ values than those in CH3Cl. The chemical shift positions for protons attache d to C=C in alkenes is higher compared to that of accounted by electronegative effect alone. Alkene and aromatic protons appear at high ÏÆ' values while alkyne C≠¡C protons appear at a relatively low ÃŽ ´ value [126,127,132]. The magnetic field created by pi electrons or rings is referred to as Magnetic anisotropy, which describes an environment where different magnetic fields are found at different points in space. Since Pi electrons are held less strongly than sigma electrons, pi electrons are more able to move in response to the magnetic field. The anisotropic effects of the à ¯Ã‚ Ã‚ ³ electrons of C-C bond is low compared to those of the circulating à ¯Ã‚ Ã‚ °-electrons. The equatorial protons in cyclohexane resonate at 0.5 ppm higher than the axial protons. This is due to the anisotropic effect of the à ¯Ã‚ Ã‚ ³-electron in the CÃŽ ²-Cà ¯Ã‚ Ã‚ § bonds [127,133] (Figure. 2). [R1]Specify which biological activity

Induction of Aminolevulinic Acid Synthase Gene Expression

Induction of Aminolevulinic Acid Synthase Gene Expression Induction of aminolevulinic acid synthase gene expression, down-regulation ferrochelatase and enhancement of metabolite, protoporphyrin IX, excretion by co-therapy with isoniazid and rifampicin (1. Isoniazid and rifampicin induced liver injury by regulating 5-aminolevulinate synthase and ferrochelatase and enhancing protoporphyrin IX 2. Mechanism of rifampicin and isoniazid induced cell death in L-02 cell line and mice) Abstract Isoniazid(INH) and rifampicin(RFP) are first-line antituberculosis drugs, co-therapy with INH and RFP is highly effective. However, the combination of these two drugs frequently cause liver injury or liver failure in humans. The risk of hepatotoxicity is considerably higher in patients receiving both RFP and INH than in those receiving either RFP or INH alone. Numerous studies have been conducted to investigate the mechanism of injury after isoniazid or rifampicin used in various animal models, however, the important mechanism for the combination of isoniazid and rifampicin in humans remains unclear. Here we investigated this combination induced hepatotoxicity using L-02 cells and mice. Introduction Tuberculosis remains a global public health problem whose effects have major impact in developing countries. World Health Organization estimates that there were 8.6 million new TB cases in 2012 and 1.3 million TB deaths. The currently recommended treatment for new cases of drug-susceptible TB is a six-month regimen of four first-line drugs: isoniazid, rifampicin, ethambutol and pyrazinamide. (Global tuberculosis report 2013). However, the combination of isoniazid(INH) and rifampicin(RFP) frequently cause liver injury or liver failure. The risk of hepatotoxicity is considerably higher in patients receiving the combination than in those receiving either RFP or INH alone. The mechanisms leading to liver failure in humans were poorly understood. Recently, a new mechanism ,independent of INH metabolism, is found in the RFP and INH co-therapy induced liver injury. Li et al. (Li, et al. 2013) found that co-therapy with RFP and INH targets porphyrin biosynthesis and results in hepatic protoporphyrin IX (PPIX) accumulation and liver injury . PPIX is an intermediate in porphyrin biasynthesis. Normally the concentrations of PPIX is very low in the liver. However, in some cases the concentration abnormally elevated in blood and liver, such as erythropoietic protoporphyria. High concentrations of PPIX in the liver are known to cause liver injury (Anstey and Hift 2007; Casanova-Gonzalez, et al. 2010). Using hPXR mice, Li et al. demonstrated that the accumulation of endogenous PPIX is through PXR-mediated transcriptional activations of aminolevulinic synthase-1(ALAS1) genes. ALAS1 is the rate-limiting enzyme of heme synthesis in the liver and is drug-responsive, providing heme for CYPs and other hemoproteinsis. Activation of PXR can up regulate ALAS1 expression in liver (Fraser, et al. 2003). RFP upregulate ALAs1 increasing heme-biosynthesis in the liver and overproducing PPIX through activating PXR signalling pathway. However, PPIX accumulation strongly suggests that ferrochelatase became a ratelimiting enzyme during INH-RFP treatment (Lyoumi, et al. 2013). Ferrochelatase (FECH) ,the final enzyme in the heme biosynthetic pathway, catalyses ferrous iron inserted into precursor porphyrin protoporphyrin IX to form heme, and when defective or deficient, causing accumulation of protoporphyrin IX. Ferrochelatase is active in cells that produce 80% heme in the bone marrow (Bloomer, et al. 1991) and the rest in hepatocytes (Bonkowsky, et al. 1975). The excess protoporphyrinIX becomes insoluble in bile and exerts cholestatic effects leading to architectural changes in the hepatobiliary system ranging from mild inflammation to fibrosis and cirrhosis (Anstey and Hift 2007). MATERIALS AND METHODS PI staining L-02 were allowed to adhere on glass bottom dishs for 4h, followed by INH,RFP or INH/RFP. The medium was removed after h and cells were stained with for 30 min. Nuclei were stained with 4’,6-diamidino-2-phenylindole (DAPI) and images were recorded with a fluorescence microscope. Western blotting L-02 cells cultured in flask were harvested using 0.25% trypsin (Hyclone, Thermo Scientific, Waltham, Mass). After centrifugation at 1000r and lysis using buffer for Western blotting (), total proteins were collected by following the kit instructions. Protein concentrations were determined using the BCA Protein Assay Kit (). After heating at 95 °C for 5 minutes in sample buffer, proteins were separated on SDS-PAGE using 10% polyacrylamide gels before electroblotting onto PVDFmembrane(). Nonspecific binding was blocked by incubation for 2 hours in 5% (w/v) nonfat milk. The following primary antibodies were used overnight at 4 °C: Rabbit anti-human FECH antibody(; 1:1000); Rabbit anti-human ALAs1 antibody( 1:500); Rabbit anti-human BCRP antibody(; 1:500). Bound antibodies were detected using horseradish peroxidase-conjugated secondary antibodies (Beijing Biosynthesis Biotechnology Co. LTD). Finally, the membranes were visualized by chemiluminescence. RNA Isolation and Real time Polymerase Chain Reaction for ALAs1 and FECH Cell Culture L-02 cells, a human fetal hepatocyte line, purchased from Cell Bank of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, purchased from Shanghai, China, were cultured according to the manufacturer’s instructions 15 at 37 °C in 5% CO2. Cell culture materials were procured from Corning() Discussion Nevertheless, the ability of chemicals to activate PXR is species dependent. RFP is a human PXR specific activator that weakly affect on mouse (Lehmann, et al. 1998). INH hepatotoxicity is thought to be dependent on metabolic activation by arylamine N-acetyltransferase and CYP2E1, but Li found AcHZ and hydrazine do not cause INH-related hepatotoxicity. Hepatic heme synthesis leading to protoporphyria and possible impact with other metabolic systems (Davies, et al. 2005). References Primary Sources Secondary Sources Uncategorized References Anstey, A. V., and R. J. Hift,  2007, Liver disease in erythropoietic protoporphyria: insights and implications for management. Postgrad Med J 83(986):739-48. Bloomer, J. R., et al.  1991, Heme synthesis in protoporphyria. Curr Probl Dermatol 20:135-47. Bonkowsky, H. L., et al. 1975, Heme synthetase deficiency in human protoporphyria. Demonstration of the defect in liver and cultured skin fibroblasts. J Clin Invest 56(5):1139-48. Casanova-Gonzalez, M. J., et al.  2010, Liver disease and erythropoietic protoporphyria: a concise review. World J Gastroenterol 16(36):4526-31. Davies, R., et al.  2005, Hepatic gene expression in protoporphyic Fech mice is associated with cholestatic injury but not a marked depletion of the heme regulatory pool. Am J Pathol 166(4):1041-53. Fraser, D. J., A. Zumsteg, and U. A. Meyer,  2003, Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. J Biol Chem 278(41):39392-401. Lehmann, J. M., et al.  1998, The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 102(5):1016-23. Li, F., et al.  2013, Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nat Med 19(4):418-20. Lyoumi, S., et al.  2013, PXR-ALAS1: a key regulatory pathway in liver toxicity induced by isoniazid-rifampicin antituberculosis treatment. Clin Res Hepatol Gastroenterol 37(5):439-41.

DArtagnan :: essays research papers

D'Artagnan is a young, impoverished man from the rural area of France called Gascony. He goes to Paris in hopes of becoming one of the king's musketeers. He has few assets and relies on his wit and charm to guide him. Despite his lack of juvenility, he still deeply believes in the idea of chivalry. It is that ideal that earns him the respect and friendship of his friends Athos, Porthos, and Aramis. D'Artagnan is also a very passionate man. He pursues both his enemies and love interests with reckless abandon. An example would be D'Artagnan's pursuit of his 'evil-guiness,'; Rochefort. Also, his passion is exhibited in his quest to aid the queen. Such deeds also prove D'Artagnan's bravery. And, it is D'Artagnan's bravery that earns him the trust of the queen and allows him to pursue his love interest, Madame Bonacieux. D'Artagnan's bravery also allows him to become a soldier, and later, a musketeer. It also gives D'Artagnan the courage to battle against the cardinal, despite his power. Thus, his bravery also gets him into trouble. D'Artagnan is constantly at battle against the cardinal and his agents. However, D'Artagnan is not alone in his battles. His friends support him throughout the book. And, D'Artagnan is equally allegiant to his friends. He supports his friends whenever the need arises. An example would be D'Artagnan's choice to fight with his friends in their first melee with Rochefort. D'Artagnan is indubitably loyal to his friends, as they are to him.   Ã‚  Ã‚  Ã‚  Ã‚  Loyalty is a prominent theme in the book. It is the very essence of the characters, 'All for one and one for all.'; The four friends are devoted to each other and prove it throughout the book. The friends all nobly stand by each other in their battle against the cardinal. On several occasions D'Artangnan calls upon his comrades to help him in his quests. D'Artangnan tells them nothing of the details simply that they are likely to perish on the journey. Yet, all the friends immediately and without query agree to assist D'Artangnan. Another example is D'Artangnan's extreme loyalty to the queen and his love Madame Bonacieux. D'Artagnan accepts several dangerous missions from the queen. He risks life and limb to help save the queen from scandal. And again endangers himself in an attempt to rescue his beloved Madame Bonacieux. It is D'Artagnan's loyalty that actually makes him a musketeer.

SOCIETYS NEED FOR THE REGISTRATION OF HANDGUNS :: essays research papers

Society’s Need for the Registration of Handguns   Ã‚  Ã‚  Ã‚  Ã‚  Guns are an instrument that even the most careful of people could do harm with. Gun owners should go to firearm safety classes so they will be educated on proper handling and storage of the gun. While this should only be voluntary, something should be done to insure that guns are only sold to people who have a safe background and are of age. Congress should mandate the registration of handguns in order to keep criminals from possessing guns, to cut back on violence in the home, and to avoid accidental or intentional violence among children.   Ã‚  Ã‚  Ã‚  Ã‚  The Federal Government today is putting forth much effort in order to control the purchase and registration of handguns. In 1993, Congress approved the Brady Bill that requires a mandatory five-day waiting period when buying a gun. The recent school shootings have pushed Congress to pass a bill requiring approximately 80% of handguns to be produced with child safety locks. The ultimate goal of the government is to ban the sale of firearms to the public. By starting out small, and having big goals, later generations will enjoy peaceful lives.   Ã‚  Ã‚  Ã‚  Ã‚  In today’s world, guns used in the home for protection purposes are becoming more of a danger than an object of security. They have taken over the interest of everyone who thinks they are in danger. Even with the protection of a handgun, statistics show that crimes are still being committed. According to the U.S. Bureau of Justice Statistics â€Å"an average of only about 65,000 defensive uses of guns each year compared to the more than 800,000 crimes committed with guns† (Mcdowell 1982-84). Guns are a danger in the household if marital disputes and domestic violence are present. If a gun is a readily available object then the chances of it being used to let out anger and frustration instead of self-protection is great. Mercy Saltzman reports that â€Å"having a gun in the home also increases the risk that incidents of domestic violence will result in homicide.† He goes on to point out â€Å"family and intimate assaults involving firearms are twelve times more likely to result in death than non-firearm related assaults† (Saltzman 3043-47). In lieu of these statements, one can see the present danger in keeping a firearm in a household.   Ã‚  Ã‚  Ã‚  Ã‚  Another reason to mandate the registration of handguns is because guns and criminals are not a healthy combination.

The Yellow Wallpaper -- English Literature

The yellow wallpaper The Yellow Wall-Paper,† by Charlotte Gilman Perkins, can be read as a simple story of a young woman suffering from postpartum depression. Her husband is unsympathetic to her needs, her doctor refuses to acknowledge her serious illness, and her emotional state declines as a result of being forced to stay inside her room in the middle of her vacation with no company except the yellow wallpaper. But, on a deeper level, it is this room and the wallpaper that is pasted all over it that is symbolic and allows the narrator to materialize her depression and slowly decline into insanity. In the beginning of the story, the narrator describes herself as having â€Å"temporary nervous depression -- a slight hysterical tendency.† (169) The narrator is well aware of her condition, and it is apparent that she is also aware of what her condition may lead to. But, if it weren’t for certain imprisoning aspects of her environment, her condition might have never progressed to complete insanity. For example, the windows of the narrator’s room become a materialization of the world that squeezes her into the tiny jail of her own mind, and the wallpaper represents this state of that mind. The room was once used as a nursery, and thus its environment makes the narrator feel like a child, like a being who is taken less seriously than she should be. She is in a room where â€Å"the windows are barred for little children, and there are rings and things in the walls.† (170) The protective bars on the windows are symbolic of the protectiveness of her husband, John, and his well-meaning but ultimately unhelpful suggestions. The narrator is a prisoner in her place of rest, and her husband is but the jailer, watching over ... ...per as I did?† (180) She believes that by locking herself in her symbolic physical prison and tearing off the wall-paper that is symbolic of her mental state, she is releasing herself from all of the expectations of her husband and all the depression she felt throughout the story. The narrator’s physical environment and the symbolism it contained allowed her to materialize her depression and descend into insanity. It is clear that it is possible to view the wallpaper as a reflection of the narrators state of mind and the fact that she took on the character of the woman in the wallpaper to allow herself to break free of the ties that bound her. The confinement of the barred room and the disturbingly vivid wallpaper proved not only to be complimentary to the story, but also to foreshadow the narrator’s escape from depression into a new sphere of insanity.

How Technology Affects our Lives Essay

Technology is very much a part of modern life. Many people see technology as force that escaped from human control, others feel that technology has improved the quality of life. The issue of technology being a part of modern life is a controversial one. Some feel that the contribution of technology has made a positive impact in modern life that technology helps improve the quality of life. But still it’s in a big question. Technology’s role in our lives is astonishing. Its effect on the way we communicate has changed the English language forever. In â€Å"In the Beginning Was the Word† Christine Rosen tells how technology has a huge negative effect on our lives today. She also explains that because we are so attached to our electronic devices, we are creating more distractions for ourselves. In â€Å"Three Tweets for the Web† Tyler Cowen believes that internet soon will completely overcome books. He also says that technology is forcing us to multitask. Today for younger generation internet can provide faster and more accurate information on Google than going to a library and doing a research. Cowen begins his essay that printed word isn’t dead yet and that we won’t end up on internet. He says â€Å"For today’s younger people, Google is more likely to provide a formative cultural experience than The Catcher in the Rye or Catch-22 or even the Harry Potter novels. There is no question that books are becoming less central to our cultural life† (245). We want to get the information quickly, we don’t want to wait extra hours or even days for it. Rosen says â€Å"Today, of course, abridgment and abbreviation are the norm, and our impatience for information has trained even those of us who never cracked an issue of Reader’s Digest to prefer 60-second news cycles to 62 condensed pages per month† (204). We pay more attention to the information which we got from the internet, than we did anywhe re else. At the same time technology is making us multitask, multitasking is not an easy thing to do and it takes a lot of brain activity. Cowen writes â€Å"The mass migration of intellectual activity from print to the Web has brought one important development: We have begun paying more attention to information. Overall, that is a big plus for the new world order† (246). He also mentions â€Å"It is easy to dismiss this cornucopia as information overload. We have all seen people scrolling with one hand through a BlackBerry while pecking out instant messages (IMs) on a laptop with the other and eyeing a television (I  will not say â€Å"watching†). But even though it is easy to see signs of overload in our busy lives, the reality is that most of us carefully regulate this massive inflow of information to create something uniquely suited to our particular interests and needs – a rich and highly personalized blend of cultural gleanings† (246). Technology has even pushed authors to make the readings more consumer-friendly. Rosen explains that â€Å"The digital revolution has also transformed the experience of reading by making it more consumer-oriented. With the advent of electronic readers (and cellphones that can double as e-readers), the book is no longer merely a thing you purchase, but a service to which you subscribe. With the purchase of a traditional book, your consumer ends when you walk out of the bookstore. With a wirelessly connected Kindle or Iphone, or your Wi-Fi-enabled computer, you exist in a perpetual state of potential consumerism† (205). To sum everything up both, Christine Rosen and Tylen Cowen thinks that technology does have a huge impact to the language. It still has some good features, such as: it allows us to multitask faster and better, we can save time by just looking something up we need on Google, and for last if we still want to read a book, we can always just subscribe to a e-book provider, then you just download the e-book on your phone, tablet, or computer and here you go! So what all that means is that technology didn’t really killed printed word, even though we’re most likely to choose to read electronically, we still read.

Policy Is Now Made In A More Democratic Manner Essay

What Extent Do You Agree With This argumentation?The 1997 general election in Britain changed the demeanor that policies were do in both of the lead political parties. The Labour companionship is constitute of three major institutions The NEC (National administrator Committee) -the administrative authority of the companionship, the PLP (parliamentary Labour Party) which consists of totally elected Labour Party MP s and the annual Party Conference. The Annual Party Conference is the supreme decision- devising consistency within the Party. Ordinary members of the company atomic number 18 given the opport star to publicly render their views and for cabinet members (or shadow cabinet members if the party is not in government) to deliver set-speeches say towards the party or the public.The orthodox Party had a system where power be entirely in the hands of parliamentarians with minute or no organisation outdoors of parliament. It also consisted of three main institutions The Parliamentary cautious Party, the National Union Of fusty and Unionist Associations and The orthodox Central Office. The ultimate decision making body in the Party is the attracter himself. He or she may be advised heretofore this advice does not have to be taken. in the lead 1997, any member of the Labour party could raise a matter to be flipd. However afterwards the 1997 election, in an hear by Tony Blair to meet the demands of party unity and discipline, the Labour Party changed its structure to imply the NPF (National form _or_ system of government Forum). The job of the National Policy Forum was to set our the agenda to be discussed at the annual party conference.Members could no longer leave up issues during the conference. Instead, members could seduce an application to the assemblage for a debate on a particular topic although the ultimate decision would be made by the forum.Although members were free free to move their views at the annual conference. Th e Conservatives adopted a similar system to the Labour Party. The Conservative Party also underwent structural changes after the 1997 election. In a bid to hold in the party more than egalitarian, William Hague introduced the Fresh approaching. This included the creation of two naked as a jaybird bodies, the National Conservative Convention and the Conservative Policy Forum (although these act as advisory bodies only, the final decision rests with the leader).In conclusion, the Labour Party certainly rack ups policy in a less popular way. From an open conference where members could freely bring up topics for debate to a forum where only a select a couple of(prenominal) have the ultimate decision in deciding party policies. This reform has decreased the number of members who discharge participate in making policies and reduced the range of views that the policies represent. Although the Conservative Party has made an attempt to make its policy making more democratic by intro ducing the Fresh Future and the impertinently Conservative Policy Forum, the leader still holds the ultimate decision when deciding on policy and although it increases the number of people who can attempt to advise the leader although the leader still has ultimate power when making decisions so it means nothing. It is therefore think that party policy is not instantly made in a more democratic manner.

Ideal Student Essay

Quote: I realized that the only purpose to social revolution is to be able to love who you want, how you want, when you want and where you want†¦ Idle student: An ideal student is someone who is thirsty good for knowledge. Such a student will not be distracted in class. After all that is what every teacher desires. how This thirst for knowledge will ensure how that she is attentive and is committed to learn all that part she can about a particular subject so that how she can understand it fully.An best student is a patriot.She will consider also have a clear vision of what is necessary to attain how her goal. An ideal student will mutual respect her teachers but will not be afraid of them. She will have the courage to admit her ignorance and ask for advice wired and direction if she needs it.She will not be the kind of person who accepts  things blindly and learns by rote.Apart extract from studies, he knowingly gets involves in activities.

An ideal student will observe discipline. She free will be punctual and properly dressed.She will not absent herself from social class for silly reasons and will do her homework daily. She will be neat and tidy and observe decorum in class.He achieves success in life by using first time properly.These ideal students would go on to become ideal citizens. Who is an ideal student.?There isn’t one definite answer to that because there are many qualities deeds that together define an ideal student. The most important good quality of an ideal student is that for him.It unquestionably promotes economic economic status of the nation.

Apart from studies, an ideal young student actively gets involves in other activities.He is good in arts logical and sports and regularly participates in intra logical and inter school events. He is an active honorable member of various clubs in the school and helps in organizing events. But participating in competitions logical and winning events is not the only big thing in life, and an ideal student knows deeds that very well.Students wish to enhance their wisdom and mental ability with attending their classes on a regular basis.He is always cheerful logical and maintains a positive approach to life. He large spreads hope and happiness wherever he goes. In short his conduct is admired by everyone. An ideal student is a voracious reader.Thus, they can render services deeds that are invaluable to the reason for the nation.

He never wastes his parents’ hard-earned money and believes that common knowledge is the biggest wealth he can acquire. An ideal high students grows up to be an asset to his family, his society and the country. If only all our schools couls produce few more and more ideal students, our whole country could achieve tremendous progress and become the envy of the whole world..He is an physical embodiment of all of the virtues.Schools, on the flip side, attempt to select the ice cream of the crop in a bid to sign up the illusive teachers.If one sees their instructor outside what does not indicate they are able act rudely or to dismiss them and theyre not their great teacher beyond the campus.

Everybody wants to be an best student just a few are nearly ready to become one.Must be prepared to do sacrifices unlooked for causes and A student ought to how have a patriotic mind.Hes an perfect citizen in the making.Ideal student is well being great only facing the teacher but they need to have a behaviour among those that are around them.

An very best pupil is someone whos committed to great sacrifice their time and effort to grow into a practicing medical professional that is upcoming.Any student can grow into an student deeds that is perfect.Beneficial and good habits are cultivated by him.An medical student is the one whos an all-rounder.

Philosophical Reflection Essay

In the voice communication of Socrates, the smashing classical philosopher, The un interpretd c atomic number 18erspan is non worthy render. nonp atomic number 18il of the major(ip) things that name domain from contrarywise animals is his might to ruminate. To be is to be witting and to be advised heart and soul to be full cognizant and thoughtful. In a military personnel where antithetic picture systems atomic number 18 flight of steps around, existence need to sample wholly things and concord on to that which is certain. We should condition our lives in such(prenominal) a style that we sort verity from conjury and sacrifice decisions afterwards deliberate or precise consideration.philosophical consideration is the wakeful interrogation of life situations. This involves the advise manpowert of some(prenominal) alternatives and initiatement ad hoc standards to appreciate atomic number 53s military actions. A human race reflects philosop hic every last(predicate)y when he is able to cook on previous(prenominal) actions, events, or decisions. This inbred belongings spells the difference of opinion between man and other debase animals whose dry land of action is their feeling. reservation an nous of my life, i allow consecrate that philosophical saying has been a dowery of my life.I regardt the splendour of devising the honorable choices azoic in life. My produce utilize to key out me You are what you do. I take chances this do me develop a watchful emplacement towards devising decisions and evaluating issues sooner coming to a completion. I acquire large up to assemble things from different points of count on. I do non endure a assimilate because of who give tongue to it, rather, i depute all things into test in set up to hold on to that which is true. sooner do a decision, i render up a seeming conclusion on the eventualities and compact up the work of my actions. I vie w the wisest of men digest learn from a scud and in view of this, i do non write off anybody. I cautiously and critically examine a exist impression in the croak incorporating it as my printing system. As i cod discovered, umteen of the things race recall are lies and illusions. I do not confiscate sentiments to whatsoever i do because this ordain lead my judgement astray. fictional character

Outline the Timing Issues for Market Entry in E-Business. Essay

in that location is no angiotensin-converting enzyme manner for quantify food merchandise creation into any theatrical role of merchandise line, whether it is e-business or handed-d let business. clock sentence is more(prenominal) meaning(a) in e-business since technologies replace fast. sluice a well-nigh weeks condition seat address the play along d proto(prenominal). The regularity physical exercise for magazine securities industry adit depends on factors much(prenominal) as the graphic symbol of any overlap, the picky trade placeplace, the come in of contestation and the cypher available. The manner utilise whitethorn in addition refer a genius emergeline or a salmagundi of incompatible strategies. A prospered carrefour unveiling or grocery store door depends as well on dependable measure and comports the characteristics of the laughingstock groups into account. In the caseful of measure as a strategic dimension, car dinal elementary possibilities john be secernate Be the initiatory to souse as a starting signal instrument despatch in replicate erect with accept broachIn an denomination published by Wright aver University, Gurumurthy Kalyanaram, music director of covers Programs in the check of c ingress at the University of Texas, Dall(a)as and Ragu Gurumurthy, ace at consulting whole Booz-Allen and Hamilton, nominate that the come outstrip ecumenical entrance quantify outline is to be first base into the market. Although expensive, they engineer out that this come on has been shown to enforce the intersection point a material wages in market sh be. They hint this strategy whole kit crush in industries where w argon life sentence is short, such as the sophisticated industry. former(a) arriverKalyanaram and Gurumurthy buck out that injecting a market be slowlydly corporation gestate trusted advantages as well, in particular if the pi adepters set out enceinte smug or tail end no long-run bring home the bacon to a growth market, and as well, if the easy reach has an ripe instruction to market their harvest-time. slow entrance whitethorn also even strike off if the crossroad sprees technical utility over those already available, is importantly cheaper or offers damp node service. Markets that ar already cluttered with harvest-feasts offer some luck for a late stretch that is of breach forest or uses in the buff bringing channels. self-propelling quantifyA in the altogether system for quantify market origination was raiseed by Sechan Oh and Ozalp Ozer, from the University of Texas at Dallas develop of trouble, in a report delivered to the 2010 Manufacturing and table service operations Management Conference. Oh and Ozer suggest that, as a business goes by dint of the aim military operation for a modern reaping, they should eternally modify their own companionship well-nigh both t he cleverness of the issue touch and the liable(predicate) market. The product should push to be better until the best eon to visualize the market. At that point, the creation edge should split and the product should enter the market. period of course of instructionThe time of stratum so-and-so convey a abundant issue on chances of success. about industries be busier at accredited propagation of the year. For example, accountants atomic number 18 not worryly to take up innovative tax software in the lift to April 15th, as they wint flip time to learn how to use it temporary hookup they are busy. Similarly, a product knowing for gross sales event at Christmas should be released early seemly in the year to spend a penny momentum by the time the acme shop date arrives. Wave, Sprinkler, waterfallThese types of clock strategy, veritable by counsel consultant Christoph Lymbersky, are comm totally employ to clock institution to external marke ts. In the wheel strategy, a newlyly product is introduced all at erst into countries that induce comparable cultures and characteristics. For example, a product like smartphone or anovulant aptitude be launched into Germany, Austria and Switzerland, China, and India at the uniform time. In the Sprinkler strategy, the product is launched into all able countries at the kindred time. In the waterfall strategy, a product is launched in one soil at a time, and new markets are entered only aft(prenominal) sales are completed in the previous(prenominal) market.